Responsibility Along with frequently asked questions it provides a framework for current best practices with the aim of improving mouse welfare. Some injections (such as footpad injec-tion) are strongly discouraged and if required must be justified on a case by case basis (CCAC, 2002). During administration mice should be protected from pain, suffering, distress or lasting harm or at least pain and distress shall be kept to a minimum (ETS 123, 1986). UBC Animal Care Committee; Policy on Acceptable Methods of Rodent Blood Withdrawal: ANIMAL CARE POLICIES, SOPs & GUIDELINES | Office of Research Services 3. ccac rat guidelines 2020 (Apr 12, 2021) This SOP follows the CCAC guidelines for acceptable injection volumes For the Survival Bleeding of Mice and rats SOP animal care, Canada Manual Restraint and Common Compound Administration Routes in Subcutaneous (SC or SQ) Injection in Rats and Mice SOP Purpose This Standard Operating Procedure (SOP) describes the procedure of subcutaneous injections into rats and mice. Mice were placed individually on a tabletop in cubicles (9 × 5 5 cm high) with 2 walls of transparent acrylic glass and 2 side walls of removable stainless steel. Canadian Council on Animal Care (1993). CCAC Guidelines on Antibody Production, Canadian Council on Animal Care (2002) Refinement and reduction in production of genetically modified mice (2003) Laboratory birds: refinements in husbandry and procedures (2001) Refining procedures for the administration of substances Canadian Council on Animal Care (CCAC) guidelines (www.ccac.ca) Recommendations Use the manufacturer’s recommended route of injection since some drugs may have adverse side effects or cause discomfort if injected via a non‐recommended route. Housing and caretaking of the mice at the K.U.Leuven partner is in accordance with the Belgian and European laws, guidelines and policies for animal experimentation, housing and care (as documented in the most recent legislation, i.e. The CCAC is the national peer-review organization responsible for setting and maintaining standards for the ethical use and care of animals used in science throughout Canada. All animal experiments were performed according to protocol number A11-290, approved by the University of British Columbia's Animal Care Committee and in direct accordance with the Canadian Council of Animal Care (CCAC) guidelines. Two high-resolution (1920 × 1080) digital video cameras (High-Definition The Canadian Council on Animal Care (CCAC) document CCAC guidelines: Mice is now available. handling and collection of blood samples from mice References: 1. Principles of administration Use committee and were consistent with Canadian Council on Animal Care guidelines.11 Digital video. (1999). Canadian Council on Animal Care (CCAC) guidelines and policies, and McGill University policies, procedures and guidelines. In: ... An evaluation of distress following intraperitoneal immunization with Freund's adjuvant in mice. Canadian Council on Animal Care (CCAC) guidelines (www.ccac.ca) 2. This SOP follows the CCAC guidelines for the injection into the tail vein in laboratory rodents. Responsibility Those trained persons listed on an approved Animal Care Committee protocol performing the procedure CCAC guidelines on acceptable immunological procedures. CCAC guidelines on antibody production (2002) and Leenaars et al. the Belgian Royal Decree of 6 April 2010 and European Directive 2010/63/EU on the protection of animals used for scientific purposes of 20 October 2010). This SOP follows the CCAC guidelines for acceptable injection volumes in rodents. Recommendations ... still involves mice in the initial immunization stage, but in vitro techniques can be used for the propagation and harvesting of Mabs from the hybridoma—therefore causing significantly Laboratory Animal Science 39(2):122-126, ISSN:0023-6764. in rats and mice using the lateral tail veins.
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